Surface Trafficking of APP and BACE in Live Cells

Amyloid‐β (Aβ)‐peptide, the major constituent of the plaques that develop during Alzheimer's disease, is generated via the cleavage of Aβ precursor protein (APP) by β‐site APP‐cleaving enzyme (BACE). Using live‐cell imaging of APP and BACE labeled with pH‐sensitive proteins, we could detect the...

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Vydáno v:Traffic
Hlavní autoři: Bauereiss, Anna, Welzel, Oliver, Jung, Jasmin, Grosse‐Holz, Simon, Lelental, Natalia, Lewczuk, Piotr, Wenzel, Eva M., Kornhuber, Johannes, Groemer, Teja W.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons A/S 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680167/
https://ncbi.nlm.nih.gov/pubmed/25712587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12270
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