A specific proteinase 3 activity footprint in α(1)-antitrypsin deficiency

α(1)-Antitrypsin (α(1)-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible. However, proteinase 3 (PR3) also produces the pathological features of chronic obstructive pulmonary disease (COPD)...

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Bibliografiske detaljer
Udgivet i:ERJ Open Res
Main Authors: Newby, Paul R., Crossley, Diana, Crisford, Helena, Stockley, James A., Mumford, Richard A., Carter, Richard I., Bolton, Charlotte E., Hopkinson, Nicholas S., Mahadeva, Ravi, Steiner, Michael C., Wilkinson, Tom M.A., Sapey, Elizabeth, Stockley, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: European Respiratory Society 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680069/
https://ncbi.nlm.nih.gov/pubmed/31403052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/23120541.00095-2019
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