Persistence of Integrase-Deficient Lentiviral Vectors correlates with the induction of STING-independent CD8(+) T cell responses

Lentiviruses are among the most promising viral vectors for in vivo gene delivery. To overcome the risk of insertional mutagenesis, integrase-deficient lentiviral vectors (IDLVs) have been developed. We show here that strong and persistent specific cytotoxic T cell (CTL) responses are induced by IDL...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Cousin, Céline, Oberkampf, Marine, Felix, Tristan, Rosenbaum, Pierre, Weil, Robert, Fabrega, Sylvie, Morante, Valeria, Negri, Donatella, Cara, Andrea, Dadaglio, Gilles, Leclerc, Claude
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679900/
https://ncbi.nlm.nih.gov/pubmed/30699352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.025
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