Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation

The metabolism of vandetanib, a tyrosine kinase inhibitor used for treatment of symptomatic/progressive medullary thyroid cancer, was studied using human hepatic microsomes, recombinant cytochromes P450 (CYPs) and flavin-containing monooxygenases (FMOs). The role of CYPs and FMOs in the microsomal m...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Indra, Radek, Pompach, Petr, Martínek, Václav, Takácsová, Paulína, Vavrová, Katarína, Heger, Zbyněk, Adam, Vojtěch, Eckschlager, Tomáš, Kopečková, Kateřina, Arlt, Volker Manfred, Stiborová, Marie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679423/
https://ncbi.nlm.nih.gov/pubmed/31295928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20143392
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