Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

Insulin receptor substrate 2 (IRS2) is a key downstream mediator of insulin and insulin-like growth factor 1 (IGF1) signalling pathways and plays a major role in liver metabolism. The aim of this study was to investigate whether IRS2 had an impact on the hepatic fibrotic process associated with chol...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Villar-Lorenzo, Andrea, Rada, Patricia, Rey, Esther, Marañón, Patricia, Arroba, Ana I., Santamaría, Beatriz, Sáiz, Jorge, Rupérez, Francisco J., Barbas, Coral, García-Monzón, Carmelo, Valverde, Ángela M., González-Rodríguez, Águeda
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679376/
https://ncbi.nlm.nih.gov/pubmed/31262748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038810
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