Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice

The sinoatrial node (SAN), the primary cardiac pacemaker, consists of a head domain and a junction/tail domain that exhibit different functional properties. However, the underlying molecular mechanism defining these two pacemaker domains remains elusive. Nkx2-5 is a key transcription factor essentia...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Li, Hua, Li, Dainan, Wang, Yuzhi, Huang, Zhen, Xu, Jue, Yang, Tianfang, Wang, Linyan, Tang, Qinghuang, Cai, Chen-Leng, Huang, Hai, Zhang, Yanding, Chen, YiPing
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2019
Soggetti:
Research Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679370/
https://ncbi.nlm.nih.gov/pubmed/31320323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.178145
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