A portable epigenetic switch for bistable gene expression in bacteria

We describe a portable epigenetic switch based on opvAB, a Salmonella enterica operon that undergoes bistable expression under DNA methylation control. A DNA fragment containing the opvAB promoter and the opvAB upstream regulatory region confers bistability to heterologous genes, yielding OFF and ON...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Olivenza, David R., Nicoloff, Hervé, Sánchez-Romero, María Antonia, Cota, Ignacio, Andersson, Dan I., Casadesús, Josep
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677893/
https://ncbi.nlm.nih.gov/pubmed/31375711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47650-2
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