The codon 72 TP53 polymorphism contributes to TSC-tumorigenesis through the Notch-Nodal axis.

We discovered that 90.3% of patients with angiomyolipomas, LAM, and tuberous sclerosis complex (TSC) carry the arginine variant of codon 72 (R72) of TP53 and that R72 increases the risk for angiomyolipoma. R72 transactivates NOTCH1 and NODAL better than the proline variant of codon 72 (P72), therefo...

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Udgivet i:Mol Cancer Res
Main Authors: Cho, Jun-Hung, Patel, Bhaumik, Bonala, Santosh, Mansouri, Hossein, Manne, Sasikanth, Vadrevu, Surya Kumari, Ghouse, Shanawaz, Kung, Che-Pei, Murphy, Maureen E., Astrinidis, Aristotelis, Henske, Elizabeth P., Kwiatkowski, David J., Markiewski, Maciej M., Karbowniczek, Magdalena
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677621/
https://ncbi.nlm.nih.gov/pubmed/31088907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1292
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