Reliability of human 3D cortical organoid generation

The differentiation of pluripotent stem cells in three-dimensional cultures can recapitulate key aspects of brain development, but protocols are prone to variable results. Here we differentiated multiple human pluripotent stem cell lines for over 100 d using our previously developed approach to gene...

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Bibliographic Details
Published in:Nat Methods
Main Authors: Yoon, Se-Jin, Elahi, Lubayna S., Pașca, Anca M., Marton, Rebecca M., Gordon, Aaron, Revah, Omer, Miura, Yuki, Walczak, Elisabeth M., Holdgate, Gwendolyn M., Fan, H. Christina, Huguenard, John R., Geschwind, Daniel H., Pașca, Sergiu P.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677388/
https://ncbi.nlm.nih.gov/pubmed/30573846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-018-0255-0
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