Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism

Here, we discovered an endogenous dafachronic acid (DA) in the socioeconomically important parasitic nematode Haemonchus contortus. We demonstrate that DA promotes larval exsheathment and development in this nematode via a relatively conserved nuclear hormone receptor (DAF-12). This stimulatory effe...

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Udgivet i:PLoS Pathog
Main Authors: Ma, Guangxu, Wang, Tao, Korhonen, Pasi K., Young, Neil D., Nie, Shuai, Ang, Ching-Seng, Williamson, Nicholas A., Reid, Gavin E., Gasser, Robin B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677322/
https://ncbi.nlm.nih.gov/pubmed/31335899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007960
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