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Structural evidence for dimer-interface driven regulation of the type II cysteine desulfurase, SufS.

SufS is a type II cysteine desulfurase and acts as the initial step in the Suf Fe-S cluster assembly pathway. In Escherichia coli this pathway is utilized under conditions of oxidative stress and is resistant to reactive oxygen species. Mechanistically this means SufS must shift between protecting a...

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Publicat a:Biochemistry
Autors principals: Dunkle, Jack A., Bruno, Michael, Outten, F. Wayne, Frantom, Patrick A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676893/
https://ncbi.nlm.nih.gov/pubmed/30571100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01122
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