Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons

HIV-associated neurocognitive disorders (HAND) remain prevalent and are aggravated by µ-opioid use. We have previously shown that morphine and other µ-opioids may contribute to HAND by inhibiting the homeostatic and neuroprotective chemokine receptor CXCR4 in cortical neurons, and this novel mechani...

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Publicat a:eNeuro
Autors principals: Nash, Bradley, Tarn, Kevin, Irollo, Elena, Luchetta, Jared, Festa, Lindsay, Halcrow, Peter, Datta, Gaurav, Geiger, Jonathan D., Meucci, Olimpia
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2019
Matèries:
New Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675873/
https://ncbi.nlm.nih.gov/pubmed/31300544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0237-19.2019
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