Morphine Increases Brain Levels of Ferritin Heavy Chain Leading to Inhibition of CXCR4-Mediated Survival Signaling in Neurons

This study focuses on the effect of μ-opioid receptor agonists on CXCR4 signaling in neurons and the mechanisms involved in regulation of neuronal CXCR4 by opiates. The data show that CXCR4 is negatively modulated by long-term morphine treatments both in vitro and in vivo; CXCR4 inhibition is caused...

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Detalhes bibliográficos
Main Authors: Sengupta, Rajarshi, Burbassi, Silvia, Shimizu, Saori, Cappello, Silvia, Vallee, Richard B., Rubin, Joshua B., Meucci, Olimpia
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664553/
https://ncbi.nlm.nih.gov/pubmed/19244528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5865-08.2009
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