Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

OBJECTIVE: Over 90% of suicide attempters have a psychiatric diagnosis, however twin and family studies suggest that the genetic etiology of suicide attempt (SA) is partially distinct from that of the psychiatric disorders themselves. Here, we present the largest genome-wide association study (GWAS)...

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Detalhes bibliográficos
Publicado no:Am J Psychiatry
Main Authors: Mullins, Niamh, Bigdeli, Tim B., Børglum, Anders D, Coleman, Jonathan R I, Demontis, Ditte, Fanous, Ayman H., Mehta, Divya, Power, Robert A., Ripke, Stephan, Stahl, Eli A, Starnawska, Anna, Anjorin, Adebayo, Corvin, Aiden, Sanders, Alan R, Forstner, Andreas J, Reif, Andreas, Koller, Anna C, Świątkowska, Beata, Baune, Bernhard T, Müller-Myhsok, Bertram, Konte, Bettina, Penninx, Brenda WJH, Pato, Carlos, Zai, Clement, Rujescu, Dan, Hougaard, David M, Quested, Digby, Levinson, Douglas F, Binder, Elisabeth B, Byrne, Enda M, Agerbo, Esben, Streit, Fabian, Mayoral, Fermin, Bellivier, Frank, Degenhardt, Franziska, Breen, Gerome, Morken, Gunnar, Turecki, Gustavo, Rouleau, Guy A, Grabe, Hans J, Völzke, Henry, Jones, Ian, Giegling, Ina, Agartz, Ingrid, Melle, Ingrid, Lawrence, Jacob, Potash, James B, Walters, James TR, Strohmaier, Jana, Shi, Jianxin, Hauser, Joanna, Biernacka, Joanna M, Vincent, John B, Kelsoe, John, Strauss, John S, Lissowska, Jolanta, Pimm, Jonathan, Smoller, Jordan W, Guzman Parra, José, Berger, Klaus, Scott, Laura J, Jones, Lisa A, Azevedo, M. Helena, Trzaskowski, Maciej, Kogevinas, Manolis, Rietschel, Marcella, Boks, Marco, Ising, Marcus, Grigoroiu-Serbanescu, Maria, Hamshere, Marian L, Leboyer, Marion, Frye, Mark, Nöthen, Markus M, Alda, Martin, Preisig, Martin, Nordentoft, Merete, Boehnke, Michael, O’Donovan, Michael C, Owen, Michael J, Pato, Michele T, Renteria, Miguel, Budde, Monika, Weissman, Myrna M, Wray, Naomi R, Bass, Nicholas, Craddock, Nicholas, Smeland, Olav B, Andreassen, Ole A, Mors, Ole, Gejman, Pablo V, Sklar, Pamela, McGrath, Patrick, Hoffmann, Per, McGuffin, Peter, Lee, Phil H, Mortensen, Preben Bo, Kahn, René S, Ophoff, Roel A, Adolfsson, Rolf, Van der Auwera, Sandra, Djurovic, Srdjan, Shyn, Stanley I, Kloiber, Stefan, Heilmann-Heimbach, Stefanie, Jamain, Stéphane, Hamilton, Steven P, McElroy, Susan L, Lucae, Susanne, Cichon, Sven, Schulze, Thomas G, Hansen, Thomas, Werge, Thomas, Air, Tracy M, Nimgaonkar, Vishwajit, Appadurai, Vivek, Cahn, Wiepke, Milaneschi, Yuri, Kendler, Kenneth S, McQuillin, Andrew, Lewis, Cathryn M
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675659/
https://ncbi.nlm.nih.gov/pubmed/31164008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2019.18080957
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