Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4

Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) are selective positive modulators of the metabotropic glutamate receptors (mGluRs) subtypes 2 and 4, with no functional cross reactivity at mGluR(1a), mGLuR(5) or mGluR(8). Modest binding for two of the [3,4-d]s is observed at the allosteric fenobam mGluR(5)...

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Publicado en:Bioorg Med Chem
Main Authors: Gates, Christina, Backos, Donald S., Reigan, Philip, Kang, Hye Jin, Koerner, Chris, Mirzaei, Joseph, Natale, N.R.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675577/
https://ncbi.nlm.nih.gov/pubmed/30143366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.08.012
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