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Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice

Genetic susceptibility to chronic pancreatitis in humans is frequently associated with mutations that increase activation of the digestive protease trypsin. Intrapancreatic trypsin activation is an early event in experimental acute pancreatitis in rodents, suggesting that trypsin is a key driver of...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Geisz, Andrea, Jancsó, Zsanett, Németh, Balázs Csaba, Hegyi, Eszter, Sahin-Tóth, Miklós
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675558/
https://ncbi.nlm.nih.gov/pubmed/31211695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129717
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