Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder

Mitochondrial dysfunction characterizes many rare and common age-associated diseases. The biochemical consequences, underlying clinical manifestations, and potential therapeutic targets, remain to be better understood. We tested the hypothesis that lipid dyshomeostasis in mitochondrial disorders goe...

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Publicado en:JCI Insight
Main Authors: Ruiz, Matthieu, Cuillerier, Alexanne, Daneault, Caroline, Deschênes, Sonia, Frayne, Isabelle Robillard, Bouchard, Bertrand, Forest, Anik, Legault, Julie Thompson, Vaz, Frederic M., Rioux, John D., Burelle, Yan, Des Rosiers, Christine
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675547/
https://ncbi.nlm.nih.gov/pubmed/31341105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123231
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