Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice

Tissue plasminogen activator (tPA) is a serine protease primarily involved in mediating thrombus breakdown and regulating catabolism of amyloid-beta (Aβ). The aim of this study is to investigate age-dependent decline of endogenous tPA and the effects of tPA decline on glymphatic function and cogniti...

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Vydáno v:Aging Dis
Hlavní autoři: Yu, Peng, Venkat, Poornima, Chopp, Michael, Zacharek, Alex, Shen, Yi, Liang, Linlin, Landschoot-Ward, Julie, Liu, Zhongwu, Jiang, Rongcai, Chen, Jieli
Médium: Artigo
Jazyk:Inglês
Vydáno: JKL International LLC 2019
Témata:
Orginal Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675536/
https://ncbi.nlm.nih.gov/pubmed/31440383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2018.0816
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