White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies

We investigated cognitive function, axonal/white matter (WM) changes and glymphatic function of vascular dementia (VaD) using a multiple microinfarction (MMI) model in retired breeder (RB) rats. The MMI model induces significant (p<0.05) cognitive decline that worsens with age starting at 2 weeks...

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Bibliografiske detaljer
Udgivet i:Neurobiol Aging
Main Authors: Venkat, Poornima, Chopp, Michael, Zacharek, Alex, Cui, Chengcheng, Zhang, Li, Li, Qingjiang, Lu, Mei, Zhang, Talan, Liu, Amy, Chen, Jieli
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209254/
https://ncbi.nlm.nih.gov/pubmed/27940353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.11.002
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