Intracranial Delivery of CLN2 Reduces Brain Pathology in a Mouse Model of Classical Late Infantile Neuronal Ceroid Lipofuscinosis

Classical late infantile neuronal ceroid lipofuscinosis (cLINCL) is a lysosomal storage disorder caused by mutations in CLN2, which encodes lysosomal tripeptidyl peptidase I (TPP1). Lack of TPP1 results in accumulation of autofluorescent storage material and curvilinear bodies in cells throughout th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Passini, Marco A., Dodge, James C., Bu, Jie, Yang, Wendy, Zhao, Qi, Sondhi, Dolan, Hackett, Neil R., Kaminsky, Stephen M., Mao, Qinwen, Shihabuddin, Lamya S., Cheng, Seng H., Sleat, David E., Stewart, Gregory R., Davidson, Beverly L., Lobel, Peter, Crystal, Ronald G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2006
Schlagworte:
Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675492/
https://ncbi.nlm.nih.gov/pubmed/16452657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2676-05.2006
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge