Toll-like receptor 4 deficiency or inhibition does not modulate survival and neurofunctional outcome in a murine model of cardiac arrest and resuscitation

BACKGROUND: Patients experiencing cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) often die or suffer from severe neurological impairment. Post resuscitation syndrome is characterized by a systemic inflammatory response. Toll-like receptor 4 (TLR4) is a major mediator of inflammation and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bergt, Stefan, Grub, Andrea, Mueller, Melanie, Bajorat, Rika, Barilar, Ivan, Vollmar, Brigitte, Roesner, Jan Patrick, Wagner, Nana-Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675321/
https://ncbi.nlm.nih.gov/pubmed/31369614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220404
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