Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter

In serotonin transporter knock-out (5-HTT−/−) mice, extracellular serotonin (5-HT) levels are markedly elevated in the brain, and rapid eye movement sleep (REMS) is enhanced compared with wild-type mice. We hypothesized that such sleep impairment at adulthood results from excessive serotonergic tone...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Alexandre, Chloé, Popa, Daniela, Fabre, Véronique, Bouali, Saoussen, Venault, Patrice, Lesch, Klaus-Peter, Hamon, Michel, Adrien, Joëlle
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675294/
https://ncbi.nlm.nih.gov/pubmed/16707806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5156-05.2006
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