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Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter
In serotonin transporter knock-out (5-HTT−/−) mice, extracellular serotonin (5-HT) levels are markedly elevated in the brain, and rapid eye movement sleep (REMS) is enhanced compared with wild-type mice. We hypothesized that such sleep impairment at adulthood results from excessive serotonergic tone...
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| Опубликовано в: : | J Neurosci |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Society for Neuroscience
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675294/ https://ncbi.nlm.nih.gov/pubmed/16707806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5156-05.2006 |
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