Ciliary Neurotrophic Factor Activates Astrocytes, Redistributes Their Glutamate Transporters GLAST and GLT-1 to Raft Microdomains, and Improves Glutamate Handling In Vivo

To study the functional role of activated astrocytes in glutamate homeostasis in vivo, we used a model of sustained astrocytic activation in the rat striatum through lentiviral-mediated gene delivery of ciliary neurotrophic factor (CNTF). CNTF-activated astrocytes were hypertrophic, expressed immatu...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Escartin, Carole, Brouillet, Emmanuel, Gubellini, Paolo, Trioulier, Yaël, Jacquard, Carine, Smadja, Claire, Knott, Graham W., Goff, Lydia Kerkerian-Le, Déglon, Nicole, Hantraye, Philippe, Bonvento, Gilles
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675222/
https://ncbi.nlm.nih.gov/pubmed/16738240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0302-06.2006
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