Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response

BACKGROUND: Previous studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell dependent inflammatory processes. Herein, we examin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sharma, Sribava, Tomar, Sunil, Dharne, Mayuri, Ganesan, Varsha, Smith, Andrew, Yang, Yanfen, Waggoner, Lisa, Wang, Yui-Hsi, Hogan, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675080/
https://ncbi.nlm.nih.gov/pubmed/31369572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219375
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