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A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca(2+)-Dependent Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis
Synaptotagmin-1, the Ca(2+) sensor for fast neurotransmitter release, was proposed to function by Ca(2+)-dependent phospholipid binding and/or by Ca(2+)-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex binding. Extensive in vivo data support the first h...
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| Publié dans: | J Neurosci |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Neuroscience
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6674888/ https://ncbi.nlm.nih.gov/pubmed/17135417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3804-06.2006 |
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