Stable Rhodopsin/Arrestin Complex Leads to Retinal Degeneration in a Transgenic Mouse Model of Autosomal Dominant Retinitis Pigmentosa

Over 100 rhodopsin mutation alleles have been associated with autosomal dominant retinitis pigmentosa (ADRP). These mutations appear to cause photoreceptor cell death through diverse molecular mechanisms. We show that K296E, a rhodopsin mutation associated with ADRP, forms a stable complex with arre...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Chen, Jiayan, Shi, Guang, Concepcion, Francis A., Xie, Guifu, Oprian, Daniel, Chen, Jeannie
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674877/
https://ncbi.nlm.nih.gov/pubmed/17108167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3212-06.2006
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