Survival Motor Neuron Function in Motor Axons Is Independent of Functions Required for Small Nuclear Ribonucleoprotein Biogenesis

Spinal muscular atrophy (SMA) is a motor neuron degenerative disease caused by low levels of the survival motor neuron (SMN) protein and is linked to mutations or loss of SMN1 and retention of SMN2. How low levels of SMN cause SMA is unclear. SMN functions in small nuclear ribonucleoprotein (snRNP)...

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Pubblicato in:J Neurosci
Autori principali: Carrel, Tessa L., McWhorter, Michelle L., Workman, Eileen, Zhang, Honglai, Wolstencroft, Elizabeth C., Lorson, Christian, Bassell, Gary J., Burghes, Arthur H. M., Beattie, Christine E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674655/
https://ncbi.nlm.nih.gov/pubmed/17065443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1637-06.2006
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