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Survival Motor Neuron Function in Motor Axons Is Independent of Functions Required for Small Nuclear Ribonucleoprotein Biogenesis

Spinal muscular atrophy (SMA) is a motor neuron degenerative disease caused by low levels of the survival motor neuron (SMN) protein and is linked to mutations or loss of SMN1 and retention of SMN2. How low levels of SMN cause SMA is unclear. SMN functions in small nuclear ribonucleoprotein (snRNP)...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Carrel, Tessa L., McWhorter, Michelle L., Workman, Eileen, Zhang, Honglai, Wolstencroft, Elizabeth C., Lorson, Christian, Bassell, Gary J., Burghes, Arthur H. M., Beattie, Christine E.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674655/
https://ncbi.nlm.nih.gov/pubmed/17065443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1637-06.2006
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