Survival Motor Neuron Function in Motor Axons Is Independent of Functions Required for Small Nuclear Ribonucleoprotein Biogenesis

Spinal muscular atrophy (SMA) is a motor neuron degenerative disease caused by low levels of the survival motor neuron (SMN) protein and is linked to mutations or loss of SMN1 and retention of SMN2. How low levels of SMN cause SMA is unclear. SMN functions in small nuclear ribonucleoprotein (snRNP)...

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Publicado no:J Neurosci
Main Authors: Carrel, Tessa L., McWhorter, Michelle L., Workman, Eileen, Zhang, Honglai, Wolstencroft, Elizabeth C., Lorson, Christian, Bassell, Gary J., Burghes, Arthur H. M., Beattie, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674655/
https://ncbi.nlm.nih.gov/pubmed/17065443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1637-06.2006
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