Cytosolic Catechols Inhibit α-Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates

Aberrant aggregation of α-synuclein (α-syn) to form fibrils and insoluble aggregates has been implicated in the pathogenic processes of many neurodegenerative diseases. Despite the dramatic effects of dopamine in inhibiting the formation of α-syn fibrils by stabilization of oligomeric intermediates...

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Pubblicato in:J Neurosci
Autori principali: Mazzulli, Joseph R., Mishizen, Amanda J., Giasson, Benoit I., Lynch, David R., Thomas, Steven A., Nakashima, Akira, Nagatsu, Toshiharu, Ota, Akira, Ischiropoulos, Harry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674486/
https://ncbi.nlm.nih.gov/pubmed/17005870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0896-06.2006
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