Neuroprotection by Transgenic Expression of Glucose-6-Phosphate Dehydrogenase in Dopaminergic Nigrostriatal Neurons of Mice

Oxidative damage to dopaminergic nigrostriatal (DNS) neurons plays a central role in the pathogenesis of Parkinson's disease (PD). Glucose-6-phosphate dehydrogenase (G6PD) is a key cytoprotective enzyme that provides NADPH, the major source of the reducing equivalents of a cell. Mutations of th...

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Pubblicato in:J Neurosci
Autori principali: Mejías, Rebeca, Villadiego, Javier, Pintado, C. Oscar, Vime, Pablo J., Gao, Lin, Toledo-Aral, Juan J., Echevarría, Miriam, López-Barneo, José
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674068/
https://ncbi.nlm.nih.gov/pubmed/16641229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0122-06.2006
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