BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

Neural precursor cells (NPCs) are highly sensitive to genotoxic injury, which triggers activation of the intrinsic mitochondria-dependent apoptotic pathway. This pathway is typically initiated by members of the BH3 (Bcl-2 homology 3)-only subgroup of the Bcl-2 (B-cell CLL/lymphoma 2) protein family,...

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Published in:J Neurosci
Main Authors: Akhtar, Rizwan S., Geng, Ying, Klocke, Barbara J., Latham, Cecelia B., Villunger, Andreas, Michalak, Ewa M., Strasser, Andreas, Carroll, Steven L., Roth, Kevin A.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673947/
https://ncbi.nlm.nih.gov/pubmed/16822983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0196-06.2006
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