Glial Progenitors in Adult White Matter Are Driven to Form Malignant Gliomas by Platelet-Derived Growth Factor-Expressing Retroviruses

To test the gliomagenic potential of adult glial progenitors, we infected adult rat white matter with a retrovirus that expresses high levels of PDGF and green fluorescent protein (GFP). Tumors that closely resembled human glioblastomas formed in 100% of the animals by 14 d postinfection. Surprising...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Assanah, Marcela, Lochhead, Richard, Ogden, Alfred, Bruce, Jeffrey, Goldman, James, Canoll, Peter
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673823/
https://ncbi.nlm.nih.gov/pubmed/16793885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0514-06.2006
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