Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis

Neuronal ceroid lipofuscinosces/Batten disease (NCL) is a devastating group of neurodegenerative diseases caused by genetic disruptions in lysosomal function. Cathepsin D (CD) is a major lysosomal protease, and mutations in CD that render it enzymatically defective have been reported recently in sub...

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Publié dans:J Neurosci
Auteurs principaux: Shacka, John J., Klocke, Barbara J., Young, Chainllie, Shibata, Masahiro, Olney, John W., Uchiyama, Yasuo, Saftig, Paul, Roth, Kevin A.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2007
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673541/
https://ncbi.nlm.nih.gov/pubmed/17314303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5577-06.2007
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