Molecular Mechanisms of Subtype-Specific Inhibition of Neuronal T-Type Calcium Channels by Ascorbate

T-type Ca(2+) channels (T-channels) are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents. Ascorbate is an endogenous redox agent that can function as both an anti- and pro-oxidant. Here, we show that ascorbate selectively inhibits native...

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Udgivet i:J Neurosci
Main Authors: Nelson, Michael T., Joksovic, Pavle M., Su, Peihan, Kang, Ho-Won, Van Deusen, Amy, Baumgart, Joel P., David, Laurence S., Snutch, Terrance P., Barrett, Paula Q., Lee, Jung-Ha, Zorumski, Charles F., Perez-Reyes, Edward, Todorovic, Slobodan M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2007
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673317/
https://ncbi.nlm.nih.gov/pubmed/18003836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2206-07.2007
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