Thr(339)-to-Serine Substitution in Rat P2X(2) Receptor Second Transmembrane Domain Causes Constitutive Opening and Indicates a Gating Role for Lys(308)

P2X(2) receptors are ATP-gated ion channels widely expressed by neurons. Thr(339) lies in the second of the two transmembrane domains of the rat P2X(2) receptor protein, and is likely to be close to the narrowest part of the pore. Single-channel and whole-cell recording after expression in human emb...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Cao, Lishuang, Young, Mark T., Broomhead, Helen E., Fountain, Samuel J., North, R. Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673282/
https://ncbi.nlm.nih.gov/pubmed/18032665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4036-07.2007
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