Expression Profiling of Huntington's Disease Models Suggests That Brain-Derived Neurotrophic Factor Depletion Plays a Major Role in Striatal Degeneration

Many pathways have been proposed as contributing to Huntington's disease (HD) pathogenesis, but generally the in vivo effects of their perturbation have not been compared with reference data from human patients. Here we examine how accurately mechanistically motivated and genetic HD models reca...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Strand, Andrew D., Baquet, Zachary C., Aragaki, Aaron K., Holmans, Peter, Yang, Lichuan, Cleren, Carine, Beal, M. Flint, Jones, Lesley, Kooperberg, Charles, Olson, James M., Jones, Kevin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673215/
https://ncbi.nlm.nih.gov/pubmed/17959817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2461-07.2007
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