PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors

In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] subunits, linking them to downstream neurotoxic signaling molecules. Perturbing NMDAR/PSD-95 interactions with a Tat peptide comp...

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Publicado no:J Neurosci
Main Authors: Cui, Hong, Hayashi, Amy, Sun, Hong-Shuo, Belmares, Michael P., Cobey, Carolyn, Phan, Thuymy, Schweizer, Johannes, Salter, Michael W., Wang, Yu Tian, Tasker, R. Andrew, Garman, David, Rabinowitz, Joshua, Lu, Peter S., Tymianski, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672641/
https://ncbi.nlm.nih.gov/pubmed/17855605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1464-07.2007
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