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“Breakthrough” Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time

Antipsychotics often lose efficacy in patients despite chronic continuous treatment. Why this occurs is not known. It is known, however, that withdrawal from chronic antipsychotic treatment induces behavioral dopaminergic supersensitivity in animals. How this emerging supersensitivity might interact...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Samaha, Anne-Noël, Seeman, Philip, Stewart, Jane, Rajabi, Heshmat, Kapur, Shitij
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672560/
https://ncbi.nlm.nih.gov/pubmed/17360921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5416-06.2007
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