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“Breakthrough” Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time

Antipsychotics often lose efficacy in patients despite chronic continuous treatment. Why this occurs is not known. It is known, however, that withdrawal from chronic antipsychotic treatment induces behavioral dopaminergic supersensitivity in animals. How this emerging supersensitivity might interact...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Samaha, Anne-Noël, Seeman, Philip, Stewart, Jane, Rajabi, Heshmat, Kapur, Shitij
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672560/
https://ncbi.nlm.nih.gov/pubmed/17360921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5416-06.2007
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