3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

We describe a novel corticotropin-releasing factor receptor 1 (CRF(1)) antagonist with advantageous properties for clinical development, and its in vivo activity in preclinical alcoholism models. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (MTIP...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Gehlert, Donald R., Cippitelli, Andrea, Thorsell, Annika, Lê, Anh Dzung, Hipskind, Philip A., Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J., Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2007
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672492/
https://ncbi.nlm.nih.gov/pubmed/17344409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4985-06.2007
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