3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

We describe a novel corticotropin-releasing factor receptor 1 (CRF(1)) antagonist with advantageous properties for clinical development, and its in vivo activity in preclinical alcoholism models. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (MTIP...

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Publicado en:J Neurosci
Main Authors: Gehlert, Donald R., Cippitelli, Andrea, Thorsell, Annika, Lê, Anh Dzung, Hipskind, Philip A., Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J., Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2007
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672492/
https://ncbi.nlm.nih.gov/pubmed/17344409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4985-06.2007
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