Cargando...

3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

We describe a novel corticotropin-releasing factor receptor 1 (CRF(1)) antagonist with advantageous properties for clinical development, and its in vivo activity in preclinical alcoholism models. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (MTIP...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Gehlert, Donald R., Cippitelli, Andrea, Thorsell, Annika, Lê, Anh Dzung, Hipskind, Philip A., Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J., Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2007
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672492/
https://ncbi.nlm.nih.gov/pubmed/17344409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4985-06.2007
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!