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Purinergic Receptor-Stimulated IP(3)-Mediated Ca(2+) Release Enhances Neuroprotection by Increasing Astrocyte Mitochondrial Metabolism during Aging
Astrocytes play an essential role in the maintenance and protection of the brain, which we reported was diminished with age. Here, we demonstrate that activation of a purinergic receptor (P2Y-R) signaling pathway, in astrocytes, significantly increases the resistance of astrocytes and neurons to oxi...
Gespeichert in:
| Veröffentlicht in: | J Neurosci |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672431/ https://ncbi.nlm.nih.gov/pubmed/17567812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1256-07.2007 |
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