Mice Lacking Central Serotonergic Neurons Show Enhanced Inflammatory Pain and an Impaired Analgesic Response to Antidepressant Drugs

A large body of literature has implicated serotonin [5-hydroxytryptamine (5-HT)] in descending modulation of nociceptive transmission. Here, we have studied the pain behavior of Lmx1b conditional knock-out mice (Lmx1b(f/f/p)), which lack 5-HT neurons in the CNS. Lmx1b(f/f/p) mutant mice showed norma...

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Publicado en:J Neurosci
Main Authors: Zhao, Zhong-Qiu, Chiechio, Santina, Sun, Yan-Gang, Zhang, Kai-Hua, Zhao, Cheng-Shui, Scott, Michael, Johnson, Randy L., Deneris, Evan S., Renner, Kenneth J., Gereau, Robert W., Chen, Zhou-Feng
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2007
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672267/
https://ncbi.nlm.nih.gov/pubmed/17537976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1623-07.2007
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