Rapid Synapse Elimination after Postsynaptic Protein Synthesis Inhibition In Vivo

To examine the role of retrograde signals on synaptic maintenance, we inhibited protein synthesis in individual postsynaptic cells in vivo while monitoring presynaptic terminals. Within 12 h, axon terminals begin to atrophy and withdraw from normal postsynaptic sites. Structural similarities between...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: McCann, Corey M., Nguyen, Quyen T., Santo Neto, Humberto, Lichtman, Jeff W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672258/
https://ncbi.nlm.nih.gov/pubmed/17537978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0627-07.2007
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