Rapid Synapse Elimination after Postsynaptic Protein Synthesis Inhibition In Vivo

To examine the role of retrograde signals on synaptic maintenance, we inhibited protein synthesis in individual postsynaptic cells in vivo while monitoring presynaptic terminals. Within 12 h, axon terminals begin to atrophy and withdraw from normal postsynaptic sites. Structural similarities between...

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Vydáno v:J Neurosci
Hlavní autoři: McCann, Corey M., Nguyen, Quyen T., Santo Neto, Humberto, Lichtman, Jeff W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672258/
https://ncbi.nlm.nih.gov/pubmed/17537978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0627-07.2007
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