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Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic Xenopus laevis Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin

To elucidate the molecular mechanisms underlying the light-sensitive retinal degeneration caused by the rhodopsin mutation P23H, which causes retinitis pigmentosa (RP) in humans, we expressed Xenopus laevis, bovine, human, and murine forms of P23H rhodopsin in transgenic X. laevis rod photoreceptors...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Tam, Beatrice M., Moritz, Orson L.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672211/
https://ncbi.nlm.nih.gov/pubmed/17715341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2245-07.2007
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