Overexpressing the Glucocorticoid Receptor in Forebrain Causes an Aging-Like Neuroendocrine Phenotype and Mild Cognitive Dysfunction

Repeated stress enhances vulnerability to neural dysfunction that is cumulative over the course of the lifespan. This dysfunction contributes to cognitive deficits observed during aging. In addition, aging is associated with dysregulation of the limbic–hypothalamic–pituitary–adrenal (LHPA) axis, lea...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Wei, Qiang, Hebda-Bauer, Elaine K., Pletsch, Amy, Luo, Jie, Hoversten, Mary T., Osetek, Andrew J., Evans, Simon J., Watson, Stanley J., Seasholtz, Audrey F., Akil, Huda
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2007
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672178/
https://ncbi.nlm.nih.gov/pubmed/17699665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0910-07.2007
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