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Conditional NF-L Transgene Expression in Mice for In Vivo Analysis of Turnover and Transport Rate of Neurofilaments
We generated mice with doxycycline control of a human neurofilament light (NF-L) transgene in the context of the absence (tTA;hNF-L;NF-L(−/−)) or presence (tTA;hNF-L;NF-L(+/−)) of endogenous mouse NF-L proteins. Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;h...
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| Izdano u: | J Neurosci |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Society for Neuroscience
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672085/ https://ncbi.nlm.nih.gov/pubmed/17475803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5299-06.2007 |
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