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Conditional NF-L Transgene Expression in Mice for In Vivo Analysis of Turnover and Transport Rate of Neurofilaments

We generated mice with doxycycline control of a human neurofilament light (NF-L) transgene in the context of the absence (tTA;hNF-L;NF-L(−/−)) or presence (tTA;hNF-L;NF-L(+/−)) of endogenous mouse NF-L proteins. Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;h...

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Bibliografische gegevens
Gepubliceerd in:J Neurosci
Hoofdauteurs: Millecamps, Stéphanie, Gowing, Geneviève, Corti, Olga, Mallet, Jacques, Julien, Jean-Pierre
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672085/
https://ncbi.nlm.nih.gov/pubmed/17475803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5299-06.2007
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